597 Outer root sheath is able to synthesise glycogen from lactate-investigating glycogen metabolism in human hair follicles
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چکیده
منابع مشابه
Glycogen metabolism in glycogen-rich erythrocytes.
High concentrations of red blood cell glycogen were visualized by el.ctron microscopy and demonstrated biochemically in amylo1 ,6-glucosidaseand phosphorylase-deficient red blood cells. Glycogen concentration decreased as a function of cell age. Similar incorporation rates of ‘4C-U-glucose into glycogen were observed in amylo-1 ,6-glucosidase-deflcient and normal erythrocytes, characterized by ...
متن کاملGlycogen metabolism in humans☆☆☆
In the human body, glycogen is a branched polymer of glucose stored mainly in the liver and the skeletal muscle that supplies glucose to the blood stream during fasting periods and to the muscle cells during muscle contraction. Glycogen has been identified in other tissues such as brain, heart, kidney, adipose tissue, and erythrocytes, but glycogen function in these tissues is mostly unknown. G...
متن کاملDifferentiation of nestin-negative human hair follicle outer root sheath cells into neurons in vitro
A specialized quiescent population of hair follicle stem cells, residing in the hair follicle outer root sheath cells (ORSCs), has previously demonstrated pluripotency for differentiation into neural stem cells (NSCs). A previous study indicated that nestin‑positive hair follicle ORSCs are able to differentiate into neurons. However, little has been reported on the isolation of nestin‑negative ...
متن کاملCytosolic & Lysosomal Glycogen Metabolism
It is now well established that the metabolism of glycogen in the l iver p roceeds h y d r o l y t i c a l l y through the lysosomal compar tment (Geddes & Taylor, 1985; Geddes et al .~ 1983; Geddes & Stratton~ 1977a,b; LCillman-Rauch 1981, 1982; Knecht & Hernandez, 1978; Brown et al., 1978; Rybicka, 1981) as well as through the well-established s y n t h e t i c phospho ry ly t i c pathways (C...
متن کاملRegulation of glycogen metabolism in cultured human muscles by the glycogen phosphorylase inhibitor CP-91149.
Pharmacological inhibition of liver GP (glycogen phosphorylase), which is currently being studied as a treatment for Type II (non-insulin-dependent) diabetes, may affect muscle glycogen metabolism. In the present study, we analysed the effects of the GP inhibitor CP-91149 on non-engineered or GP-overexpressing cultured human muscle cells. We found that CP-91149 treatment decreased muscle GP act...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2019
ISSN: 0022-202X
DOI: 10.1016/j.jid.2019.07.601